Biomedical Engineering Course Description

16:125:506 Artificial Implants (3)

This course presents basic concepts concerning structure and properties of materials used to replace soft and hard biological tissues. Emphasis will be placed on understanding the physical properties of the tissue to be replaced through development of structure-property relationships. Properties to be discussed include phase transitions, mechanical and hydrodynamic properties. A brief introduction will be given to processes used for form biomaterials as well as biocompatibility criteria for skin, tendon, bone, cardiovascular and other applications.

16:125:509 Medical Device Development (3)

This course details the development of medical devices that employ primarily polymeric materials in their construction. Course work will include concepts involving materials selection, feasibility studies, prototype fabrication, functionality testing, prototype final selection, biocompatibility considerations, efficacy testing, sterilization validation, FDA regulatory approaches, writing of IDE, 510(k) and PMAs, device production and record keeping. Examples used include materials for cardiovascular stents and for non-invasive measurements of tissue mechanical properties. For 2010 we will have discuss the development of cartilage substitutes. Several former graduates in BME from Rutgers will give lectures on industrial aspects of medical device development.

16:125:546 Modeling Of BME Systems (3)

This course is intended to introduce senior undergraduate-level BME students to tools and applications of chaos and pattern formation in biological systems.

16:125:564 Advanced Microscopy Lab (3)

Laboratory-based course. Quantitative and hands-on microscopy course with emphasis on the theory of image formation, mechanisms of optical contrast generation, and engineering design of state-of-the-art microscopic instrumentation.

16:125:571 Biosignal Processing and Biomedical Imaging (3)
Application of basic signal analysis to biological signals and the analysis of medical image.  Extensive use of the MATLAB language in example and problems. Prerequisites:  Graduate Standing

16:125:572 Biocontrol, Modeling and Computation (3)
Application of control theory to the analysis of biological systems.  As foundation for other biomedical engineering courses, topics include (biocontrol) control systems principles, Nyguist and root locus stability  analysis; (modeling) Nernst membrane model, action potential, cardiac and vascular mechanics, accommodation and vergence eye movements, saccades, pharmacokinetic models; and numerical solutions to different equations, computer methods using C++, and image processing of biological systems. Prerequisites:  Graduate Standing

16:125:573 Kinetics, Thermodynamics and Transport in Biomedicine (3) Fall
Intended for those seeking familiarity with the effects of, and tools to deal with, fluid, multiphase, chemical, and thermal transport and kinetics problems in biological systems. Prerequisites:  Graduate Standing

16:125:574 Biomechanics Systems (3)
Foundation in basic engineering statics, dynamics, and strength of materials is expected.  An introduction to graduate level continuum mechanics with an emphasis on biomedical and biomaterial applications. Prerequisites:  Graduate Standing

16:125:581 Mammalian Physiology (3)
This advanced physiology course is organized around integrarice issues, i.e., focus is on the physiological parameter to be controlled and to show how the different systems (nervous, endocrine, respiratory, cardiovascular, renal, gastrointestinal) contribute to homeostatis of a particular parameter.   

(Other Rutgers or RWJMS Physiology Courses – Contact the Graduate Program for information)

16:125:582 Nano-And Micro-Engineered Biointerfaces (3)
This course introduces students to the methods and mechanisms for engineering interfaces on the nano- and micro-scale.  Two approaches to engineering interfaces, generally classified as synthesis and fabrication, specifically include: i) preparing substrates that have nano- and/or micro-scale features; and ii) creating anao and/or micro-scale substrates.  The substrate materials discussed will typically consist of ceramics, polymers, and metals whereas biological systems will comprise cells, genes and ligands. Prerequisites:  Background in undergraduate chemistry, general biology, physics, and interest in integrative studies of biological interfaces.  Students concerned about their preparation should contact the instructor.

16:125:601 Engineering Ethics and Seminar (1) Fall
Each Fall semester all students are expected to attend the Seminar Series.  First year students are required to take this course which coincides with the Seminar Series in BME. Every other week, students will have a discussion about ethics in engineering and medicine.  On the alternating weeks, students will hear speakers from within and outside the Rutgers/RWJ community present their research results.

16:125:602 Engineering Writing and Seminar (1) Spring
Each Spring semester all students are expected to attend the Seminar Series.  Every other week, students will learn how to successfully write a “white paper” on subjects in BME.  On the alternating weeks, students will hear speakers from within and outside the Rutgers/RWJ community present their research results.

16:125:618 Innovation and Entrepreneurship for Science and Technology (3)

The course arms the student with the knowledge and perspective needed to evaluate their research for commercial application, to legally protect their innovation, to seek financial resources for venture monetization, to market and present their ideas to interested parties, and to document their venture details within a business plan. With innovation case studies focused upon engineering in the life and physical sciences, and team-based projects to develop feasibility and business plans, the student can easily bridge the current graduate curriculum, focused upon engineering and science, to its natural and successful application in the business world. 

16:125:628 Clinical Practicum (1) Spring
Students are introduced to clinical aspects of biomedical engineering by attending regular grand rounds given by clinical specialists from medical schools and hospitals. Selected demonstrations of clinical procedures with applications of modern technology. 

16:148:519 Cellular and Genetic Mechanisms (6) (Fall)
Beginning with a consideration of basic cellular constituents and cell and tissue types, this course reviews cellular processes in the cytoplasm, cell and organellar membranes and the nucleus.  Uses of recombinant DNA technology in investigating gene structure and function and in diagnosing genetic diseases complement examination of inheritance patterns in humans and review of genetic loci that underlie human disease.

16:148:530 Human Genetics (3) (Fall)
Examination of molecular and chromosomal bases for human inherited diseases. Molecular approaches to gene identification, including position cloning and linkage analysis. Role of mutations, evaluation of repetitive sequences in the human genome. Prerequisite: By Permission of Instructor

16:148:550 Advanced Developmental Biology (3) (Spring)Molecular mechanisms of cell type differentiation and body part specification. Cell-cell interaction, signal transduction during development, morphogenetic gradients, pattern formation, focusing on three experimental organisms: the nematode C. elegans, Drosophila, and the mouse. Genetic experimental approaches will be emphasized.

16:150:532 Kinetics Of Materials Systems (3) (Spring)
Diffusion in solids. Solutions to Fick’s first and second laws under important boundary conditions. Ionic diffusion. Diffusion applied to sintering. Solid-state reaction kinetics. Nucleation, crystal growth, and precipitation.

16:155:501 Advanced Transport Phenomena I (3) (Fall)

Momentum transport processes in laminar and turbulent flow systems. Development and application of steady and unsteady boundary layer processes including growth, similitude principles, and separation. Potential flow theory coupled with viscous dissipation at boundaries. Momentum transport in fixed and fluid bed exchangers and reactors.

16:155:502 Advanced Transport Phenomena II  (3) (Spring)
Energy balances derived from first and second law approaches to open systems, with reaction. Conduction in fluids and solids, both steady and unsteady examples. Convection in laminar and turbulent flow systems. Diffusion and its treatment in stagnant and flowing media. Two phase systems, coupled reaction and mass transfer. Interphase transport.  

16:155:514 Kinetics, Catalysis, And Reactor Design  (3) (Spring)
Principles of applied chemical kinetics, reaction mechanisms and rate laws, and engineering design of reactor vessels. Applications to homogeneous and heterogeneous process reaction systems with internal, transphase, and external mass transfer. Noncatalytic gas-solid reaction and gas-liquid absorption with reaction. Micromixing and macromixing in reactor systems. Prerequisites: 16:155:501 and 507, or equivalent.

16:155:531 Biochemical Engineering (3) (Spring)
Integration of the principles of chemical engineering, biochemistry, and microbiology. Development and application of biochemical engineering principles. Analysis of biochemical and microbial reactions.

16:155:541 Pharmaceutical Materials Engineering (3) (Fall)
Introduction to pharmaceutical materials and its application to designing and manufacturing drug products.  Focus is on materials encountered in the pharmaceutical industry and how the materials affect processes they are used in.  The course focuses on the choice of materials, troubleshooting and optimization.

16:155:551 Polymer Science and Engineering I  (3) (Spring)Physical and chemical structure of polymers; morphology of polymer crystals; microscopic texture. Mechanical properties; influence of orientation; effects of temperature and environment; engineering applications.

16:155:552 Polymer Science and Engineering II (3) (Fall)
Emphasis on a modern treatment of polymers, including statistical mechanics scaling concepts and polymer properties and characterization.

16:155:588 Special Topics: Fundamentals Of Nanoscale Thermodynamics (3) (Fall)

Covers the theoretical and multiscale simulation methods which bridge macroscopic thermodynamics and continuum transport theories with atomistic quantum mechanics and molecular dynamics

16:160:537 Biophysical Chemistry I (3) (Fall)
Introduction to the physical chemistry of proteins, nucleic acids, and their complexes. Forces that determine biopolymer structure. Principles of protein and nucleic acid structure. Transitions and interactions of biopolymers.

16:198:503 Computational Thinking (3) (Fall)
Intended for students who have not had undergraduate preparation in the subject. May not be taken for credit toward a graduate degree in computer science. Models of computation and complexity. Sorting, stacks, queues, linked lists, trees, search trees, hashing, heaps, graphs, and graph algorithms.

16:198:510 Numerical Analysis (3) (Fall)
Derivation, analysis, and application of methods used to solve numerical problems with computers; solution of equations by iteration, approximation of functions, differentiation and quadrature, differential equations, linear equations and matrices, least squares.

16:198:535 Pattern Recognition Theory and Applications (3) (Fall)
Pattern recognition as an inductive process, statistical classification, parametric and nonparametric methods, adaptive methods, error estimation, applications in image processing, character, speech recognition, and diagnostic decision making.

16:198:580 Topics In Computers In Biomedicine (3) (Fall)
A survey of computational methods in biology or medicine; topics vary from instructor to instructor and may include computational molecular biology, medical reasoning, and imaging. Prerequisite: 16:198:513 or 520

16:332:521  Digital Signals And Filters (3) (Fall) 
Sampling and quantization of analog signals; z-transforms; digital filter structures and hardware realizations; digital filter design methods; DFT and FFT methods and their application to fast convolution and spectrum estimation; introduction to discrete-time random signals.  Corequisite: 16:332:501

16:332:583 Semiconductor Devices I (3) (Fall)
Charge transport, diffusion and drift current, injection, lifetime, recombination, and generation processes, p-n junction devices, transient behavior, FET’s, I-V, and frequency characteristics, MOS devices C-V, C-f, and I-V characteristics, operation of bipolar transistors.

16:332:584 Semiconductor Devices II (3) (Spring)
Review of microwave devices, O- and M-type devices, microwave diodes, Gunn, IMPATT, TRAPATT, etc., scattering parameters and microwave amplifiers, heterostructures and III-V compound-based BJTs and FETs. 

16:332:591 Optoelectronics I (3) (Fall)
Principles of laser action, efficiency, CW and pulse operation, mode locking, output coupling, equivalent circuits, gaseous and molecular lasers, solid-state lasers, single and double heterojunction lasers, different geometrics, fabrication, degradation, and application to holography, communication, medicine, and fusion.

16:642:573, 574 Numerical Analysis (3,3) (Fall/Spring)
Ideas and techniques of numerical analysis illustrated by problems in the approximation of functions, numerical solution of linear and nonlinear systems of equations, approximation of matrix eigen-values and eigenvectors, numerical quadrature, and numerical solution of ordinary differential equations.

16:650:512 Robotics and Mechatronics  (3) (Fall)
Introduction to robotics, including mechanisms and control theories as well as applications; manipulator mechanics; design considerations; control fundamentals; adaptive and sensory controls; algorithm development; robotic assembly techniques. Prerequisites: Undergraduate vibrations, controls, and design of mechanisms.

16:650:518 Biomechanical Systems (3) (Spring)
Selected topics from the study of the human body as a mechanical system, with emphasis on modeling, analysis, and design. Investigation of biomechanical systems frequently encountered in orthopedic surgery and physical rehabilitation.

16:650:606 Microfluidic And Nanofluidic Systems (3) (Fall)
Understand the major categories, tools, components and applications of microfluidic and nanofluidic systems. Microfabrication, physicochemical description of hydrodynamics, low Reynolds number flows and other phenomena will be discussed.

16:681:502 Molecular Genetics (3) (Spring)
Prokaryotic and eukaryotic molecular genetics. Bacteria, bacterio-phage, yeast, Drosophila, and mammals. Prerequisites: 16:115:501 and 502.

16:681:530 Introduction To Molecular Medicine (3) (Spring)
Application of molecular and cell biology to a wide variety of human diseases; recent advances in understanding basic mechanisms.

16:681:543 Current Concepts Of Immunology (3) (Spring)Cellular basis of immunology; analysis, activation, and function of lymphoid cells; regulatory mechanisms, relevance to tumor and transplantation immunity.

16:681:555 Molecular Virology (3) (Spring)
Detailed consideration of fundamental physical-chemical properties, schemes of classification, genetics, and modes of replication of selected animal viruses. Prerequisite: 16:681:501 and 502 or permission of instructor

16:681:585 Cancer Molecular Biology (3) (Spring)
Emphasis on the molecular, cellular, and genetic basis for cancer. Oncogenes and tumor suppressor genes. Signal transduction and cell cycle control in cancer cells. Metastasis. Diagnosis and therapy. Recent understanding of the molecular basis of selected human cancers. Lectures and critical discussion of the current literature.

16:960:584 Biostatistics I (3) (Fall)
Statistical techniques for biomedical data. Analysis of observational studies emphasized. Topics include measures of disease frequency and association; inferences for dichotomous and grouped case-control data; logistic regression for identification of risk factors; Poisson models for grouped data; Cox model for continuous data; life table analysis; and SAS used in analysis of data. Prerequisites: 16:960:563 OR 586 OR 590 OR 593

16:960:585 Biostatistics II (3) (Spring)
Statistical techniques used in design and analysis of controlled clinical experiments. Topics include introduction to four phases of clinical trials; randomization, blocking, stratification, balancing, power, and sample-size calculation; data monitoring and interim analyses; baseline covariate adjustment; crossover trials; brief introduction to categorical and event-time data; and SAS used in analysis of data. Prerequisite: Level IV Statistics