Chemical and Bio chemical engineering course content


16:155:501 (F) Advanced Transport Phenomena I (3)
Momentum transport processes in laminar- and turbulent-flow systems. Development and application of steady and unsteady boundary-layer processes, including growth, similitude principles, and separation. Potential flow theory coupled with viscous dissipation at boundaries. Momentum transport in fixed- and fluid-bed exchangers and reactors.

16:155:502 (S) Advanced Transport Phenomena II (3)
Energy balances derived from first and second law approaches to open systems, with reaction. Conduction in fluids and solids, both steady and unsteady examples. Convection in laminar- and turbulent-flow systems. Diffusion and its treatment in stagnant and flowing media. Two-phase systems, coupled reaction, and mass transfer. Interphase transport

16:155:504 (S) Mixing: Theory and Applications (3)
Theory of mixing processes in laminar and turbulent flows. Practical aspects of mixing processes (equipment selection, design, scale-up) used in industrial operations.

16:155:506 Fluid Particles and Granular Flow (3)  
Flow of granular materials and fluid-particle suspensions. Continuum and discrete modeling, process equipment. Applications in the chemical and pharmaceutical industries addressing hydrodynamics, mixing, segregation, granulation, and reactive multiphase flows.

16:155:507 (F) Analytical Methods in Chemical and Biochemical Engineering (3)
Analytical solutions to deterministic mathematical models encountered in chemical and biochemical engineering, including environmental and safety systems. Emphasis is on purpose, philosophy, classification, development, and analytical solutions of models occurring in transport phenomena, thermochemical, and reactor systems.

16:155:508 (F) Chemical Engineering Analysis (3)  
Mathematical modeling and simulation of chemical and biochemical systems; numerical methods. Solution of ordinary and partial differential equations. Statistical methods of linear and nonlinear regression analysis; optimization methods. Extensive use of digital computers.

16:155:509 Computational Methods in Chemical and Biochemical Engineering (3)
Numerical methods used to analyze spatiotemporal dynamical systems. Emphasis on applications.

16:155:511 (F) Advanced Chemical Engineering Thermodynamics (3)
Basic principles of classical chemical thermodynamics. Chemical and physical equilibria and their relationships in simple and reactive systems. Estimation and correlation of thermodynamic functions, applications of thermodynamic principles to transport and rate processes. Irreversible and statistical thermodynamic topics also introduced.

16:155:512 Advanced Chemical Engineering Molecular Thermodynamics (3)
Statistical ensembles; ideal and nonideal gases; liquids; distribution function theories; Ornstein-Zernike equation; computer simulation methods; perturbation theories; engineering semiempirical equations of state; applications to chemical engineering systems.

16:155:513 (F) Fundamentals of Nanoscale Thermodynamics and Transport (3)
Introduction to theoretical and multiscale simulation methods applied to thermodynamics and transport in nanoscale chemical and biological systems, including nanoparticles and nanocomposites, porous materials, nanostructured colloids and surfaces, self-assembled surfactant and polymeric systems, lipid bilayers, and cell membranes.

16:155:514 (S) Kinetics, Catalysis, and Reactor Design (3)
Principles of applied chemical kinetics, reaction mechanisms and rate laws, and engineering design of reactor vessels. Applications to homogeneous and heterogeneous process reaction systems with internal, transphase, and external mass transfer. Noncatalytic gas-solid reaction and gas-liquid absorption with reaction. Micromixing and macromixing in reactor systems.

16:155:518 (S) Process Systems Engineering (3)
Key issues in process synthesis and design and process operations. Mathematical modeling, algorithmic development and optimization. Computer-aided tools. Applications: planning and scheduling of batch/continuous processes, energy integration in industrial plants, uncertainty evaluation and consideration in plant design. Case studies.

16:155:531 (F) Biochemical Engineering (3)
Integration of the principles of chemical engineering, biochemistry, and microbiology. Development and application of biochemical engineering principles. Analysis of biochemical and microbial reactions.

16:155:532 (F) Topics in Biochemical Engineering (3)
Advanced course devoted to current topics of interest in biochemical and enzyme engineering. Topics include production, isolation, and purification of enzymes; downstream processing; design and analysis of bioreactors; bioprocess economics; modeling, optimization, and scale-up of biochemical systems. Content and format may vary from year to year.

16:155:533 (S) Bioseparations (3)
Fundamental problems of separation processes important to the recovery of products from biological processes. Topics include membrane filtration centrifugation, chromatography, extraction, electrokinetic methods. Emphasis on protein separations.

16:155:541 Pharmaceutical Materials Engineering (3)
Applications to designing and optimizing pharmaceutical processes and products.  Production, characterization, and usage of pharmaceutical materials. The relationship between pharmaceutical materials and pharmaceutical products.

16:155:542 Chemical Processing of Drugs and Fine Chemicals (3)
Chemical process operations and engineering methods used in the development, scale-up, and manufacture of drugs and fine chemicals; design and regulatory compliance methods for batch multiproduct plants.

16:155:543 Industrial Chemistry of Drugs and Fine Chemicals (3)
Chemical process development, scale-up, and regulatory environment of drugs and fine chemicals; strategies and technologies for the synthesis and semisynthesis of drugs. Transition from the bench to the FDA-approved plant.

16:155:544 Pharmaceutical Organic Nanotechnology (3)
An introduction to organic nanotechnology and its application to manufacturing drug products. Industrial pharmaceutical examples, including nanoparticle and nanocomposite synthesis.

16:155:545 Pharmaceutical Process Design I (Synthesis, Separations, and Sterile Processing)
An introduction to synthesis, separations, and sterile processing and their applications to designing and optimizing pharmaceutical processes. Industrial pharmaceutical examples, including separation, distillation, crystallization, filtration, lyophilization, and drying processes.

16:155:546 Pharmaceutical Process Design II (Unit Operations) (3)
An introduction to the essential operations used in the manufacture of pharmaceutical products.  The pharmaceutical product life cycle, variability, testing, and specifications of pharmaceutical ingredients. Unit operations including blending, granulation, fluidized bed operations, milling, capsule filling, compaction, tablet coating, and other processes will be addressed. How the output of one process is the input to the next process, and how deviations can cascade along the production sequence until they cause process failures. Design, scale-up, troubleshooting, and optimization.

16:155:547 Statistical Analysis and Design of Pharmaceutical Operations (3)
An introduction to statistical analysis and experimental design methods and their applications to designing and optimizing pharmaceutical processes. Classic statistical concepts and methods using pharmaceutical examples including product/process development scenarios, routine in-process and finished product testing, and failure investigations. Regulatory requirements for test of samples, sampling plans, tablet and capsule assay, content uniformity, hardness, friability, dissolution, and bioavailability tests.

16:155:548 Advanced Topics in Pharmaceutical Engineering (3)
Thermochemical process safety; physiochemical methods at the bulk/dosage form interface; and surface chemistry of crystallization, extraction, and adsorption.

16:155:549 Advanced Engineering Pharmaceutical Kinetics, Thermodynamics, and Transport Processes (3)
Thermodynamics of pharmaceutical systems, phase diagram, phase equilibrium, and chemical equilibrium; diffusive and convective transport in pharmaceutical processes; chemical and pharmacokinetics and reaction engineering of pharmaceutical systems.

16:155:550 Computational Methods for Pharmaceutical Nanomaterials (3)
An introduction to organic nanotechnology and its application to manufacturing drug products, using industrial pharmaceutical examples, including nanoparticle and nanocomposite synthesis.

16:155:551 (F) Polymer Science and Engineering I (3)
Physical and chemical structure of polymers; morphology of polymer crystals; microscopic texture. Mechanical properties; influence of orientation; effects of temperature and environment; engineering applications.

16:155:552 Polymer Science and Engineering II (3)
Emphasis on a modern treatment of polymers, including statistical mechanics scaling concepts and polymer properties and characterization.

16:155:588,589 (F) Special Problems in Chemical Environmental Engineering (3,3)